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Sionna Therapeutics, Inc. (NASDAQ:SION)

US · Delayed Price · Currency is USD
4.70-0.12 (-2.49%)
 
Market Cap212.21M-83.5%
Revenue (ttm)0
Net Income-97.38M-28.4%
EPS-2.18-26.5%
Shares Out45.15M
PE Ration/a
Forward PEn/a
Dividendn/a
Ex-Dividend Daten/a
Volume18,296
Open4.78
Previous Close4.82
Day's Range4.65 - 4.78
52-Week Range4.01 - 54.97
Beta1.32
AnalystsHold
Price Target27.40(+482.98%)
Earnings DateNov 4, 2026
-2.28% (1D)
No price history available.
Insider Score
––Not scored
SION Insider Score

Insiders filed in the last 90 days, but none of those trades qualified for scoring — round-trip buys and filings whose price is far off the market are excluded.

About SION

Sionna Therapeutics, Inc., a clinical-stage biopharmaceutical company, researches and develops medicines for the treatment of cystic fibrosis (CF). It develops galicaftor (SION-2222), a transmembrane domain 1 (TMD1)-directed cystic fibrosis transmembrane conductance regulator (CFTR) that has completed Phase 2 trial; navocaftor (SION-3067), a potentiator that has completed Phase 2 trial; SION-109, an intracellular loop 4 directed CFTR corrector that has completed Phase 1 trial; SION-2851, a TMD1-directed CFTR corrector that has completed Phase 1 trial; SION-451, which is nucleotide-binding domain 1 stabilizer in Phase 1 trial; and SION-719, which is nucleotide-binding domain 1 stabilizer in Phase 2a proof-of-concept trial. The company was formerly known as Sling Therapeutics, Inc. and changed its name to Sionna Therapeutics, Inc. in July 2021. Sionna Therapeutics, Inc. was incorporated in 2019 and is headquartered in Waltham, Massachusetts.

Address
21 Hickory Drive Suite 500, Waltham, MA, 02451, US
Market Cap
212 million
Employees
59
Industrial Classification
Biotechnology

What Are Insiders Doing?

Open-market buy / sell balanceNet Selling
Sold
$113.85M
Bought
$0

View the trades behind this meter — each links to its SEC Form 4 →

Open-market Form 4 purchases (code P) vs sales (code S) on file for this company. Grants, option exercises and tax withholdings are excluded. Informational only.

1 Day
-2.49%
5 Days
-9.44%
1 Month
-35.62%
6 Months
-87.28%
1 Year
-83.51%

$SION stock is featured in our Insider Score Rankings, and Insider Trades datasets.

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Recently reported changes in SION holdings by institutional investors

Scanning latest 13F filings…

Latest 0 13F filings · Source: SEC EDGAR

View all institutional owners →

Insider Trading

Quarterly net insider trading by SION's directors and management

Net Shares Purchased by Insiders−4M−2M02025Q42026Q12026Q22026Q32026Q4

Source: SEC EDGAR (Form 4)

Corporate Lobbying

SION Estimated quarterly lobbying spending

Source: U.S. Senate LDA

U.S. Patents

New SION patent grants

Loading patent grants…

Source: USPTO Open Data Portal

Government Contracts

Estimated quarterly amount awarded to SION from public contracts

Source: USAspending.gov

Top ETF Holders

ETFs with the largest estimated holdings in SION

ETFEst. Holding Size
VTIVanguard Morningstar Total Stock Market ETF$5.64M
VFMOVanguard U.S. Momentum Factor ETF$2.42M
IWMiShares Russell 2000 ETF$2.33M
VXFVanguard Extended Market ETF$1.01M
IBBiShares Biotechnology ETF$968.82K
IWOiShares Russell 2000 Growth ETF$842.13K

Estimated from each fund’s disclosed top holdings × AUM

SION Insider Score

Our composite score: insider buying, sector, volume, tone & dilution

Members only

The live Insider Score for SION is included with Insider Access.

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Bull Case vs Bear Case

AI-generated from SION’s recent data — informational, not investment advice

Generating analysis…

Insider Score

Our 0–100 Insider Score and the signals behind it.

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The live Insider Score and its full factor breakdown are included with Insider Access.

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Recent Insider Activity

Buys
0
Sells
23
Buy Value
$0
Distinct Buyers
0

Frequently Asked Questions

Disclaimer — Informational only — not investment advice. Insider transaction data is sourced from SEC Form 4 filings; market data from public feeds and may be delayed. The Insider Score is a proprietary score for research purposes and does not predict future performance. Always do your own research.