Key points
- BLSM (BlossomHill Therapeutics) carries a Very Strong Insider Score with $25.2M in insider purchases — the highest conviction signal on this list.
- Four of the top five stocks are healthcare or pharmaceutical names, reflecting significant insider buying appetite in the sector.
- Combined insider purchases across all five names total $56.1M, historically associated with periods of elevated insider confidence.
When insiders buy in size, they're putting their own capital on the line — a powerful signal that conviction runs deep. Our Insider Score feed ranks stocks by the strength and consistency of insider buying activity, separating casual transactions from genuine bets on future performance. The five stocks below represent the highest conviction levels in the market right now, each backed by substantial insider purchases and strong score bands. Here's what the filings show.
1. BLSM — Healthcare Leader With Exceptional Insider Conviction
BlossomHill Therapeutics carries a Very Strong Insider Score — the highest band on our scale — supported by $25.2 million in total insider purchases. This level of aggregate buying historically suggests deep confidence from company leadership and board members. Investors may want to monitor this name closely, as Very Strong Insider Scores have been historically associated with periods of outperformance in healthcare stocks.
- Insider Score band: Very Strong — the highest conviction tier on our feed.
- Total insider purchases: $25.2M — substantially larger than peers on this list.
- Why it matters: Healthcare insiders deploying this level of capital may signal confidence in pipeline, clinical data, or strategic positioning.
2. TLSA — Life Sciences Biotech With Strong Insider Backing
Tiziana Life Sciences Ltd holds a Strong Insider Score based on $1.04 million in insider purchases. The company operates in the life sciences space, where insider buying often precedes clinical advances or partnership announcements. This score suggests meaningful confidence from those closest to the company's operations.
- Insider Score band: Strong — indicating substantive insider conviction.
- Total insider purchases: $1.04M — a focused bet by company insiders.
- Why it matters: In biotech, insider buying typically signals optimism about near-term catalysts or unannounced developments.
3. FEMY — Smaller-Cap Healthcare With Insider Support
FEMASYS INC rounds out the healthcare trio with a Strong Insider Score underpinned by $134,000 in insider purchases. While the dollar amount is modest, the consistency of insider buying across multiple shareholders may suggest coordinated confidence. Smaller-cap healthcare names often see more outsized moves when insider conviction solidifies.
- Insider Score band: Strong — same tier as peers despite lower absolute dollars.
- Total insider purchases: $134K — concentrated but meaningful for a smaller capitalization.
- Why it matters: Insider buys on smaller-cap names can have greater percentage impact if conviction translates to stock performance.
4. NTHI — Pharmaceutical Preparations With Steady Insider Interest
NEONC TECHNOLOGIES HOLDINGS, INC. operates in pharmaceutical preparations and carries a Strong Insider Score backed by $458,438 in insider purchases. This level of buying suggests meaningful conviction from company insiders in the drug development or manufacturing cycle. Pharmaceutical insiders typically hold detailed knowledge of pipeline progress and regulatory timelines.
- Insider Score band: Strong — consistent with the broader healthcare trend on this list.
- Total insider purchases: $458.4K — mid-range conviction signal.
- Why it matters: Pharmaceutical insiders buying steady amounts may signal confidence in product approvals or market uptake.
5. PNAQ — Acquisition Vehicle With Substantial Insider Commitment
Pinnacle Acquisition Corp rounds out the top five with a Strong Insider Score supported by $29.8 million in insider purchases — the second-highest dollar amount on this list. As a special purpose acquisition company (SPAC), this level of insider buying into the vehicle may signal confidence in target selection or deal structuring. SPAC insiders typically have visibility into upcoming announcements.
- Insider Score band: Strong — matching other high-conviction names.
- Total insider purchases: $29.8M — second only to BLSM by dollar volume.
- Why it matters: Large insider commitments to SPAC vehicles historically have preceded merger announcements or positive deal news.
The Bottom Line
These five stocks represent the strongest insider conviction signals in the market right now, with combined purchases exceeding $56 million and all but one carrying Very Strong or Strong Insider Scores. Healthcare and pharmaceutical insiders are particularly active, which may suggest confidence in regulatory or clinical timelines ahead. To explore the full Insider Score rankings and track the latest insider activity, visit our live Insider Score feed — updated daily with Form 4 filings and congressional trades.