XBI State Street SPDR S&P Biotech ETF
Issuer
SPDR
Inception
Jan 31, 2006
AUM
$10.4B
Expense ratio
0.35%
Yield
0.37%
Asset class
Equity
Holdings
165
Last price
$148.91
SPDR Series Trust - State Street SPDR S&P Biotech ETF is an exchange traded fund launched by State Street Global Advisors, Inc. The fund is managed by SSGA Funds Management, Inc. It invests in public equity markets of the United States. It invests in stocks of companies operating across health care, pharmaceuticals, biotechnology and life sciences sectors. The fund invests in growth and value stocks of companies across diversified market capitalization. It seeks to track the performance of the S&P Biotechnology Select Industry Index, by using representative sampling technique. SPDR Series Trust - State Street SPDR S&P Biotech ETF was formed on January 31, 2006 and is domiciled in the United States.
+33.4%
2025-11-13low 111.91 · high 169.552026-11-13
Performance
| 1M | 3M | YTD | 1Y | 3Y ann. | 5Y ann. | |
|---|---|---|---|---|---|---|
| XBI | +1.4% | -5.1% | +22.1% | +33.1% | +30.3% | +3.8% |
| Equity average (4725 funds) | -2.2% | -4.7% | +3008.3% | +1886.0% | +15.1% | +2.6% |
Insider activity in the holdings
Open-market insider buying across this fund’s holdings over 90 days, weighted by holding weight: +$2.9M net.
| Holding | Weight | Insiders bought | Insiders sold |
|---|---|---|---|
| KOD KODIAK SCIENCES INC | 1.37% | $181.3M | $2.7M |
| MDGL MADRIGAL PHARMACEUTICALS INC | 1.15% | $35.0M | $7.0M |
| SRRK SCHOLAR ROCK HOLDING CORP | 0.83% | $12.0M | $0 |
| PRTA PROTHENA CORP PLC | 0.08% | $9.8M | $0 |
| INBX INHIBRX BIOSCIENCES INC | 0.29% | $6.3M | $279K |
| KURA KURA ONCOLOGY INC | 0.19% | $2.4M | $1.7M |
| RGNX REGENXBIO INC | 0.16% | $949K | $0 |
| ALNY ALNYLAM PHARMACEUTICALS INC | 0.90% | $543K | $399K |
| DMRA DAMORA THERAPEUTICS INC | 0.17% | $253K | $0 |
| ANNX ANNEXON INC | 0.24% | $100K | $0 |
| DYN DYNE THERAPEUTICS INC | 0.77% | $40K | $248K |
| VNDA VANDA PHARMACEUTICALS INC | 0.07% | $38K | $0 |
| PGEN PRECIGEN INC | 0.26% | $25K | $2.3M |
| CMPX COMPASS THERAPEUTICS INC | 0.04% | $21K | $0 |
| TYRA TYRA BIOSCIENCES INC | 0.24% | $20K | $0 |
Holdings · as of Nov 12, 2026
| # | Holding | Weight |
|---|---|---|
| 1 | MRNA MODERNA INC | 2.66% |
| 2 | SYRE SPYRE THERAPEUTICS INC | 1.78% |
| 3 | EXEL EXELIXIS INC | 1.76% |
| 4 | TGTX TG THERAPEUTICS INC | 1.74% |
| 5 | BIIB BIOGEN INC | 1.74% |
| 6 | AMGN AMGEN INC | 1.73% |
| 7 | REGN REGENERON PHARMACEUTICALS | 1.72% |
| 8 | ABBV ABBVIE INC | 1.70% |
| 9 | UTHR UNITED THERAPEUTICS CORP | 1.70% |
| 10 | ORKA ORUKA THERAPEUTICS INC | 1.70% |
| 11 | GILD GILEAD SCIENCES INC | 1.69% |
| 12 | NBIX NEUROCRINE BIOSCIENCES INC | 1.63% |
| 13 | ALKS ALKERMES PLC | 1.53% |
| 14 | VRTX VERTEX PHARMACEUTICALS INC | 1.52% |
| 15 | BBIO BRIDGEBIO PHARMA INC | 1.51% |
| 16 | PRAX PRAXIS PRECISION MEDICINES I | 1.45% |
| 17 | ROIV ROIVANT SCIENCES LTD | 1.45% |
| 18 | TWST TWIST BIOSCIENCE CORP | 1.42% |
| 19 | KYMR KYMERA THERAPEUTICS INC | 1.41% |
| 20 | INCY INCYTE CORP | 1.41% |
| 21 | NTRA NATERA INC | 1.40% |
| 22 | PTCT PTC THERAPEUTICS INC | 1.39% |
| 23 | ERAS ERASCA INC | 1.38% |
| 24 | KOD KODIAK SCIENCES INC | 1.37% |
| 25 | HALO HALOZYME THERAPEUTICS INC | 1.37% |
| 26 | INSM INSMED INC | 1.36% |
| 27 | PTGX PROTAGONIST THERAPEUTICS INC | 1.34% |
| 28 | PCVX VAXCYTE INC | 1.34% |
| 29 | BMRN BIOMARIN PHARMACEUTICAL INC | 1.31% |
| 30 | RYTM RHYTHM PHARMACEUTICALS INC | 1.30% |
| 31 | KRYS KRYSTAL BIOTECH INC | 1.29% |
| 32 | RVMD REVOLUTION MEDICINES INC | 1.26% |
| 33 | CRSP CRISPR THERAPEUTICS AG | 1.22% |
| 34 | DNTH DIANTHUS THERAPEUTICS INC | 1.21% |
| 35 | GRAL GRAIL INC | 1.21% |
| 36 | MDGL MADRIGAL PHARMACEUTICALS INC | 1.15% |
| 37 | CYTK CYTOKINETICS INC | 1.14% |
| 38 | MIRM MIRUM PHARMACEUTICALS INC | 1.14% |
| 39 | TVTX TRAVERE THERAPEUTICS INC | 1.14% |
| 40 | COGT COGENT BIOSCIENCES INC | 1.12% |
| 41 | CGON CG ONCOLOGY INC | 1.10% |
| 42 | CDNA CAREDX INC | 1.05% |
| 43 | TNGX TANGO THERAPEUTICS INC | 1.03% |
| 44 | VKTX VIKING THERAPEUTICS INC | 0.96% |
| 45 | RLAY RELAY THERAPEUTICS INC | 0.94% |
| 46 | ALNY ALNYLAM PHARMACEUTICALS INC | 0.90% |
| 47 | IOVA IOVANCE BIOTHERAPEUTICS INC | 0.89% |
| 48 | BEAM BEAM THERAPEUTICS INC | 0.87% |
| 49 | ARWR ARROWHEAD PHARMACEUTICALS IN | 0.87% |
| 50 | ARQT ARCUTIS BIOTHERAPEUTICS INC | 0.84% |
| 51 | RARE ULTRAGENYX PHARMACEUTICAL IN | 0.83% |
| 52 | SRRK SCHOLAR ROCK HOLDING CORP | 0.83% |
| 53 | DYN DYNE THERAPEUTICS INC | 0.77% |
| 54 | IMVT IMMUNOVANT INC | 0.77% |
| 55 | IBRX IMMUNITYBIO INC | 0.77% |
| 56 | VRDN VIRIDIAN THERAPEUTICS INC | 0.76% |
| 57 | CELC CELCUITY INC | 0.76% |
| 58 | IONS IONIS PHARMACEUTICALS INC | 0.73% |
| 59 | VCEL VERICEL CORP | 0.64% |
| 60 | IRON DISC MEDICINE INC | 0.61% |
| 61 | SMMT SUMMIT THERAPEUTICS INC | 0.59% |
| 62 | DNLI DENALI THERAPEUTICS INC | 0.59% |
| 63 | ADMA ADMA BIOLOGICS INC | 0.59% |
| 64 | RXRX RECURSION PHARMACEUTICALS A | 0.58% |
| 65 | PVLA PALVELLA THERAPEUTICS INC | 0.58% |
| 66 | VCYT VERACYTE INC | 0.57% |
| 67 | BHVN BIOHAVEN LTD | 0.55% |
| 68 | VERA VERA THERAPEUTICS INC | 0.55% |
| 69 | AGIO AGIOS PHARMACEUTICALS INC | 0.55% |
| 70 | PURR HYPERLIQUID STRATEGIES | 0.54% |
| 71 | REPL REPLIMUNE GROUP INC | 0.53% |
| 72 | BCRX BIOCRYST PHARMACEUTICALS INC | 0.52% |
| 73 | XNCR XENCOR INC | 0.51% |
| 74 | IDYA IDEAYA BIOSCIENCES INC | 0.51% |
| 75 | ABSI ABSCI CORP | 0.49% |
| 76 | QURE UNIQURE NV | 0.49% |
| 77 | SRPT SAREPTA THERAPEUTICS INC | 0.48% |
| 78 | NTLA INTELLIA THERAPEUTICS INC | 0.48% |
| 79 | CLDX CELLDEX THERAPEUTICS INC | 0.47% |
| 80 | SLS SELLAS LIFE SCIENCES GROUP I | 0.47% |
| 81 | NVAX NOVAVAX INC | 0.45% |
| 82 | ACAD ACADIA PHARMACEUTICALS INC | 0.45% |
| 83 | TRAX FIRST TRACKS BIOTHERAPEU W/I | 0.43% |
| 84 | RCUS ARCUS BIOSCIENCES INC | 0.38% |
| 85 | NKTR NEKTAR THERAPEUTICS | 0.37% |
| 86 | IMNM IMMUNOME INC | 0.36% |
| 87 | STOK STOKE THERAPEUTICS INC | 0.36% |
| 88 | NRIX NURIX THERAPEUTICS INC | 0.35% |
| 89 | VIR VIR BIOTECHNOLOGY INC | 0.33% |
| 90 | ANAB ANAPTYSBIO INC | 0.31% |
| 91 | MNKD MANNKIND CORP | 0.29% |
| 92 | ZBIO ZENAS BIOPHARMA INC | 0.29% |
| 93 | INBX INHIBRX BIOSCIENCES INC | 0.29% |
| 94 | JBIO JADE BIOSCIENCES INC | 0.28% |
| 95 | PGEN PRECIGEN INC | 0.26% |
| 96 | ANNX ANNEXON INC | 0.24% |
| 97 | SNDX SYNDAX PHARMACEUTICALS INC | 0.24% |
| 98 | TYRA TYRA BIOSCIENCES INC | 0.24% |
| 99 | MLYS MINERALYS THERAPEUTICS INC | 0.23% |
| 100 | ARDX ARDELYX INC | 0.22% |
| 101 | TSHA TAYSHA GENE THERAPIES INC | 0.22% |
| 102 | VOR VOR BIOPHARMA INC | 0.22% |
| 103 | ORIC ORIC PHARMACEUTICALS INC | 0.21% |
| 104 | GLUE MONTE ROSA THERAPEUTICS INC | 0.21% |
| 105 | RIGL RIGEL PHARMACEUTICALS INC | 0.21% |
| 106 | CRVS CORVUS PHARMACEUTICALS INC | 0.20% |
| 107 | VSTM VERASTEM INC | 0.20% |
| 108 | COAG HEMAB THERAPEUTICS HOLDINGS | 0.20% |
| 109 | CADL CANDEL THERAPEUTICS INC | 0.20% |
| 110 | CAPR CAPRICOR THERAPEUTICS INC | 0.20% |
| 111 | KURA KURA ONCOLOGY INC | 0.19% |
| 112 | GERN GERON CORP | 0.18% |
| 113 | IMMX IMMIX BIOPHARMA INC | 0.17% |
| 114 | KLRA KAILERA THERAPEUTICS INC | 0.17% |
| 115 | OLMA OLEMA PHARMACEUTICALS INC | 0.17% |
| 116 | DMRA DAMORA THERAPEUTICS INC | 0.17% |
| 117 | RGNX REGENXBIO INC | 0.16% |
| 118 | MYGN MYRIAD GENETICS INC | 0.16% |
| 119 | IRWD IRONWOOD PHARMACEUTICALS INC | 0.16% |
| 120 | SVRA SAVARA INC | 0.16% |
| 121 | PRME PRIME MEDICINE INC | 0.15% |
| 122 | FDMT 4D MOLECULAR THERAPEUTICS IN | 0.15% |
| 123 | SGMT SAGIMET BIOSCIENCES INC A | 0.14% |
| 124 | JANX JANUX THERAPEUTICS INC | 0.14% |
| 125 | CGEM CULLINAN THERAPEUTICS INC | 0.14% |
| 126 | QUIT ACHIEVE LIFE SCIENCES INC | 0.13% |
| 127 | SLDB SOLID BIOSCIENCES INC | 0.13% |
| 128 | CLYM CLIMB BIO INC | 0.13% |
| 129 | AVTX AVALO THERAPEUTICS INC | 0.12% |
| 130 | SANA SANA BIOTECHNOLOGY INC | 0.12% |
| 131 | AVBP ARRIVENT BIOPHARMA INC | 0.12% |
| 132 | BCAX BICARA THERAPEUTICS INC | 0.11% |
| 133 | ABUS ARBUTUS BIOPHARMA CORP | 0.11% |
| 134 | CTMX CYTOMX THERAPEUTICS INC | 0.11% |
| 135 | OCGN OCUGEN INC | 0.10% |
| 136 | EDIT EDITAS MEDICINE INC | 0.10% |
| 137 | DSGN DESIGN THERAPEUTICS INC | 0.10% |
| 138 | MNPR MONOPAR THERAPEUTICS INC | 0.10% |
| 139 | EBS EMERGENT BIOSOLUTIONS INC | 0.10% |
| 140 | STTK SHATTUCK LABS INC | 0.09% |
| 141 | AKTS AKTIS ONCOLOGY INC | 0.09% |
| 142 | SPRY ARS PHARMACEUTICALS INC | 0.08% |
| 143 | ALT ALTIMMUNE INC | 0.08% |
| 144 | ALLO ALLOGENE THERAPEUTICS INC | 0.08% |
| 145 | PRTA PROTHENA CORP PLC | 0.08% |
| 146 | OVID OVID THERAPEUTICS INC | 0.08% |
| 147 | VNDA VANDA PHARMACEUTICALS INC | 0.07% |
| 148 | CABA CABALETTA BIO INC | 0.07% |
| 149 | AURA AURA BIOSCIENCES INC | 0.07% |
| 150 | XBI CONTRA METSERA INC | 0.07% |
| 151 | ASMB ASSEMBLY BIOSCIENCES INC | 0.07% |
| 152 | NGNE NEUROGENE INC | 0.07% |
| 153 | MDXG MIMEDX GROUP INC | 0.06% |
| 154 | CBIO CRESCENT BIOPHARMA INC | 0.05% |
| 155 | LXEO LEXEO THERAPEUTICS INC | 0.05% |
| 156 | CMPX COMPASS THERAPEUTICS INC | 0.04% |
| 157 | FTH FAETH THERAPEUTICS INC | 0.03% |
| 158 | BBOT BRIDGEBIO ONCOLOGY THERAPEUT | 0.02% |
| 159 | 2200964D OMNIAB INC 15.00 EARNOUT | 0.00% |
| 160 | 2200963D OMNIAB INC 12.5 EARNOUT | 0.00% |
Sector breakdown
Healthcare99.5%
Financial Services0.5%
Country breakdown
United States96.7%
United Kingdom1.4%
Switzerland1.3%
Netherlands0.5%
Ireland0.1%
China0.0%
Distributions
| Date | Per unit |
|---|---|
| Jun 22, 2026 | $0.1381 |
| Dec 22, 2025 | $0.4066 |
| Sep 22, 2025 | $0.0267 |
| Jun 23, 2025 | $0.0073 |
| Mar 24, 2025 | $0.0053 |
| Dec 23, 2024 | $0.0027 |
| Sep 23, 2024 | $0.0152 |
| Jun 24, 2024 | $0.1148 |
| Dec 18, 2023 | $0.0139 |
| Jun 20, 2023 | $0.0026 |
| Mar 22, 2021 | $0.0400 |
| Dec 21, 2020 | $0.1760 |
| Sep 21, 2020 | $0.0890 |
| Jun 22, 2020 | $0.0168 |
| Dec 20, 2019 | $0.0009 |
| Sep 20, 2019 | $0.0032 |
| Dec 21, 2018 | $0.0120 |
| Sep 21, 2018 | $0.0730 |
| Jun 15, 2018 | $0.0580 |
| Mar 16, 2018 | $0.0590 |
| Dec 15, 2017 | $0.0350 |
| Sep 15, 2017 | $0.0370 |
| Jun 16, 2017 | $0.1100 |
| Mar 17, 2017 | $0.0200 |
| Dec 16, 2016 | $0.0180 |
| Sep 16, 2016 | $0.0310 |
| Jun 17, 2016 | $0.0460 |
| Mar 18, 2016 | $0.0580 |
| Dec 18, 2015 | $0.1490 |
| Sep 18, 2015 | $0.0500 |
| Jun 19, 2015 | $0.1460 |
| Mar 20, 2015 | $0.0817 |
| Dec 19, 2014 | $0.1637 |
| Sep 19, 2014 | $0.1877 |
| Jun 20, 2014 | $0.2053 |
| Mar 21, 2014 | $0.1110 |
| Dec 20, 2013 | $0.0127 |
| Sep 20, 2013 | $0.0291 |
| Jun 21, 2013 | $0.0173 |
| Mar 15, 2013 | $0.0147 |
Members of Congress who disclosed this ETF
| Member | Action | Amount band | Date |
|---|---|---|---|
| Tommy Tuberville · Senate · R | Buy | $1K–$15K | May 8, 2024 |
| John F. Reed · Senate · D | Sell | $1K–$15K | Mar 9, 2018 |
| John F. Reed · Senate · D | Buy | $1K–$15K | Jun 19, 2017 |
| John F. Reed · Senate · D | Buy | $1K–$15K | Mar 6, 2017 |
Fund facts, prices, performance and distributions: our market-data vendor. Holdings: the vendor and SEC Form N-PORT. Insider and Congress data: InsiderBuying. Last updated Nov 13, 2026. This is historical data, not investment advice. Report a data error