TDNA T. Rowe Price Biotech ETF
Issuer
T. Rowe
Inception
Sep 16, 2026
AUM
$11.1M
Expense ratio
0.55%
Yield
—
Asset class
Equity
Holdings
0
Last price
$24.32
T. Rowe Price Biotech ETF is an actively managed exchange-traded fund that seeks long-term capital appreciation by investing primarily in biotechnology and life sciences companies. The fund focuses on companies developing innovative therapies, medicines, and technologies across areas such as biotechnology, pharmaceuticals, and medical research. T. Rowe Price lists the fund under the ticker TDNA.
-4.6%
2026-09-17low 22.72 · high 25.652026-11-13
Performance
| 1M | 3M | YTD | 1Y | 3Y ann. | 5Y ann. | |
|---|---|---|---|---|---|---|
| TDNA | +5.4% | -4.6% | -4.6% | -4.6% | -1.6% | -0.9% |
| Equity average (4625 funds) | -2.1% | +2.7% | +87.6% | +61193.5% | +13.9% | +2.3% |
Insider activity in the holdings
Open-market insider buying across this fund’s holdings over 90 days, weighted by holding weight: +$6.3M net.
| Holding | Weight | Insiders bought | Insiders sold |
|---|---|---|---|
| KOD KODIAK SCIENCES INC COMMON STOCK USD.0001 | 3.10% | $181.3M | $2.7M |
| ADRX ADARX PHARMACEUTICALS INC COMMON STOCK USD.0001 | 0.16% | $87.7M | $0 |
| LYCA LYCIA THERAPEUTICS INC COMMON STOCK USD.0001 | 0.22% | $38.5M | $0 |
| MDGL MADRIGAL PHARMACEUTICALS INC COMMON STOCK USD.0001 | 1.03% | $35.0M | $7.0M |
| SRRK SCHOLAR ROCK HOLDING CORP COMMON STOCK USD.001 | 1.58% | $12.0M | $0 |
| CTY CITY THERAPEUTICS INC COMMON STOCK | 0.18% | $6.1M | $0 |
| XENE XENON PHARMACEUTICALS INC COMMON STOCK | 0.80% | $1.7M | $426K |
| EIKN EIKON THERAPEUTICS INC COMMON STOCK USD.0001 | 0.29% | $1.0M | $0 |
| ALNY ALNYLAM PHARMACEUTICALS INC COMMON STOCK USD.01 | 1.07% | $543K | $399K |
| DYN DYNE THERAPEUTICS INC COMMON STOCK USD.0001 | 1.33% | $40K | $248K |
| TYRA TYRA BIOSCIENCES INC COMMON STOCK USD.0001 | 0.62% | $20K | $0 |
Holdings · as of Nov 13, 2026
| # | Holding | Weight |
|---|---|---|
| 1 | ARGX ARGENX SE ADR ADR | 5.41% |
| 2 | KYMR KYMERA THERAPEUTICS INC COMMON STOCK USD.0001 | 4.78% |
| 3 | KOD KODIAK SCIENCES INC COMMON STOCK USD.0001 | 3.10% |
| 4 | INSM INSMED INC COMMON STOCK USD.01 | 2.69% |
| 5 | MRNA MODERNA INC COMMON STOCK USD.0001 | 2.41% |
| 6 | PCVX VAXCYTE INC COMMON STOCK USD.001 | 2.39% |
| 7 | PRAX PRAXIS PRECISION MEDICINES I COMMON STOCK USD.0001 | 2.26% |
| 8 | RYTM RHYTHM PHARMACEUTICALS INC COMMON STOCK | 2.19% |
| 9 | UTHR UNITED THERAPEUTICS CORP COMMON STOCK USD.01 | 2.14% |
| 10 | SYRE SPYRE THERAPEUTICS INC COMMON STOCK USD.0001 | 2.10% |
| 11 | RVMD REVOLUTION MEDICINES INC COMMON STOCK | 2.05% |
| 12 | BBIO BRIDGEBIO PHARMA INC COMMON STOCK | 1.99% |
| 13 | VRTX VERTEX PHARMACEUTICALS INC COMMON STOCK USD.01 | 1.98% |
| 14 | DNTH DIANTHUS THERAPEUTICS INC COMMON STOCK USD.001 | 1.95% |
| 15 | MIRM MIRUM PHARMACEUTICALS INC COMMON STOCK | 1.89% |
| 16 | CGON CG ONCOLOGY INC COMMON STOCK | 1.80% |
| 17 | ALKS ALKERMES PLC COMMON STOCK USD.01 | 1.79% |
| 18 | NTRA NATERA INC COMMON STOCK | 1.76% |
| 19 | TNGX TANGO THERAPEUTICS INC COMMON STOCK USD.0001 | 1.69% |
| 20 | CYTK CYTOKINETICS INC COMMON STOCK USD.001 | 1.66% |
| 21 | RLAY RELAY THERAPEUTICS INC COMMON STOCK USD.001 | 1.64% |
| 22 | ERAS ERASCA INC COMMON STOCK USD.0001 | 1.63% |
| 23 | SRRK SCHOLAR ROCK HOLDING CORP COMMON STOCK USD.001 | 1.58% |
| 24 | VRDN VIRIDIAN THERAPEUTICS INC COMMON STOCK USD.01 | 1.50% |
| 25 | IRON DISC MEDICINE INC COMMON STOCK USD.0001 | 1.48% |
| 26 | TVTX TRAVERE THERAPEUTICS INC COMMON STOCK USD.0001 | 1.39% |
| 27 | DYN DYNE THERAPEUTICS INC COMMON STOCK USD.0001 | 1.33% |
| 28 | ARWR ARROWHEAD PHARMACEUTICALS IN COMMON STOCK USD.001 | 1.24% |
| 29 | BIIB BIOGEN INC COMMON STOCK USD.0005 | 1.23% |
| 30 | TDNA Cash/Cash equivalent USD | 1.21% |
| 31 | XNCR XENCOR INC COMMON STOCK USD.01 | 1.20% |
| 32 | IMVT IMMUNOVANT INC COMMON STOCK USD.0001 | 1.17% |
| 33 | BEAM BEAM THERAPEUTICS INC COMMON STOCK USD.01 | 1.13% |
| 34 | ROIV ROIVANT SCIENCES LTD COMMON STOCK USD.0000001 | 1.12% |
| 35 | GRAL GRAIL INC COMMON STOCK | 1.10% |
| 36 | DNLI DENALI THERAPEUTICS INC COMMON STOCK USD.01 | 1.08% |
| 37 | CLDX CELLDEX THERAPEUTICS INC COMMON STOCK USD.001 | 1.08% |
| 38 | TWST TWIST BIOSCIENCE CORP COMMON STOCK USD.00001 | 1.07% |
| 39 | ALNY ALNYLAM PHARMACEUTICALS INC COMMON STOCK USD.01 | 1.07% |
| 40 | ORKA ORUKA THERAPEUTICS INC COMMON STOCK USD.001 | 1.05% |
| 41 | REPL REPLIMUNE GROUP INC COMMON STOCK USD.001 | 1.04% |
| 42 | PVLA PALVELLA THERAPEUTICS INC COMMON STOCK USD.001 | 1.04% |
| 43 | MDGL MADRIGAL PHARMACEUTICALS INC COMMON STOCK USD.0001 | 1.03% |
| 44 | AMGN AMGEN INC COMMON STOCK USD.0001 | 1.02% |
| 45 | GILD.TO GILEAD SCIENCES INC COMMON STOCK USD.001 | 0.97% |
| 46 | VERA VERA THERAPEUTICS INC COMMON STOCK USD.001 | 0.94% |
| 47 | REGN REGENERON PHARMACEUTICALS COMMON STOCK USD.001 | 0.92% |
| 48 | KRYS KRYSTAL BIOTECH INC COMMON STOCK USD.00001 | 0.91% |
| 49 | IDYA IDEAYA BIOSCIENCES INC COMMON STOCK USD.0001 | 0.90% |
| 50 | ASND ASCENDIS PHARMA A/S COMMON STOCK DKK1.0 | 0.90% |
| 51 | COGT COGENT BIOSCIENCES INC COMMON STOCK USD.001 | 0.83% |
| 52 | XENE XENON PHARMACEUTICALS INC COMMON STOCK | 0.80% |
| 53 | TRAX FIRST TRACKS BIOTHERAPEU W/I COMMON STOCK | 0.79% |
| 54 | HALO HALOZYME THERAPEUTICS INC COMMON STOCK USD.001 | 0.77% |
| 55 | SMMT SUMMIT THERAPEUTICS INC COMMON STOCK USD.01 | 0.76% |
| 56 | PTGX PROTAGONIST THERAPEUTICS INC COMMON STOCK USD.00001 | 0.74% |
| 57 | ABSI ABSCI CORP COMMON STOCK USD.0001 | 0.73% |
| 58 | STOK STOKE THERAPEUTICS INC COMMON STOCK | 0.72% |
| 59 | NRIX NURIX THERAPEUTICS INC COMMON STOCK | 0.68% |
| 60 | GLUE MONTE ROSA THERAPEUTICS INC COMMON STOCK USD.0001 | 0.67% |
| 61 | TYRA TYRA BIOSCIENCES INC COMMON STOCK USD.0001 | 0.62% |
| 62 | IONS IONIS PHARMACEUTICALS INC COMMON STOCK USD.001 | 0.58% |
| 63 | CGEM CULLINAN THERAPEUTICS INC COMMON STOCK USD.0001 | 0.53% |
| 64 | CELC CELCUITY INC COMMON STOCK USD.001 | 0.49% |
| 65 | MLYS MINERALYS THERAPEUTICS INC COMMON STOCK USD.0001 | 0.49% |
| 66 | ORIC ORIC PHARMACEUTICALS INC COMMON STOCK USD.0001 | 0.47% |
| 67 | VCYT VERACYTE INC COMMON STOCK USD.001 | 0.43% |
| 68 | RCUS ARCUS BIOSCIENCES INC COMMON STOCK USD.0001 | 0.42% |
| 69 | ANRO ALTO NEUROSCIENCE INC COMMON STOCK USD.0001 | 0.40% |
| 70 | AGIO AGIOS PHARMACEUTICALS INC COMMON STOCK USD.001 | 0.40% |
| 71 | ELVN ENLIVEN THERAPEUTICS INC COMMON STOCK USD.001 | 0.40% |
| 72 | CRVS CORVUS PHARMACEUTICALS INC COMMON STOCK USD.0001 | 0.39% |
| 73 | CMPS COMPASS PATHWAYS PLC ADR USD.008 | 0.37% |
| 74 | TRVI TREVI THERAPEUTICS INC COMMON STOCK | 0.36% |
| 75 | LBRX LB PHARMACEUTICALS INC COMMON STOCK USD.0001 | 0.36% |
| 76 | GH GUARDANT HEALTH INC COMMON STOCK USD.00001 | 0.36% |
| 77 | CLYM CLIMB BIO INC COMMON STOCK | 0.31% |
| 78 | DFTX DEFINIUM THERAPEUTICS INC COMMON STOCK | 0.31% |
| 79 | EIKN EIKON THERAPEUTICS INC COMMON STOCK USD.0001 | 0.29% |
| 80 | GENB GENERATE BIOMEDICINES INC COMMON STOCK | 0.28% |
| 81 | AVLN AVALYN PHARMA INC COMMON STOCK USD.001 | 0.27% |
| 82 | ABVX ABIVAX SA ADR ADR EUR.01 | 0.25% |
| 83 | LYCA LYCIA THERAPEUTICS INC COMMON STOCK USD.0001 | 0.22% |
| 84 | FTH FAETH THERAPEUTICS INC COMMON STOCK | 0.19% |
| 85 | CTY CITY THERAPEUTICS INC COMMON STOCK | 0.18% |
| 86 | ADRX ADARX PHARMACEUTICALS INC COMMON STOCK USD.0001 | 0.16% |
Sector breakdown
Healthcare100.0%
Country breakdown
United States97.5%
United Kingdom1.5%
Canada0.8%
France0.2%
Distributions
No distributions on file.
Members of Congress who disclosed this ETF
No member of Congress has disclosed a trade in TDNA in the filings we hold.
Fund facts, prices, performance and distributions: our market-data vendor. Holdings: the vendor and SEC Form N-PORT. Insider and Congress data: InsiderBuying. Last updated Nov 13, 2026. This is historical data, not investment advice. Report a data error